Zakir Hussain was born in Kaimganj, Farrukhabad (U.P), India His family migrated from Hyderabad to Kaimganj, where Hussain grew up. Hussain's father, Fida Hussain Khan, died when he was ten years old; his mother died in 1911 when he was fourteen. Dr. Zakir Hussain was father to two daughters, Sayeeda Khan and Safia Rahman. Fida Hussain and Naznin Begum had seven sons-
Muzaffar Hussain Khan; started his judicial career in Hyderabad but died of tuberculosis at the young age of 28. Eminent linguist and the 5th Vice Chancellor of Jamia Millia
Professor Emeritus Masud Husain Khan is his son.
Abid Hussain Khan; died young of tuberculosis.
Zahid Hussain Khan; died young of tuberculosis.